Tuesday, July 28, 2026

Smoking Toad for Higher Consciousness: The Ego Trip by Kimon de Greef

 The Ego Trip: Psychedelic Toads, a Trail of Deaths, and the Guru Who Peddled Transcendence by Kimon de Greef

The Ego Trip book cover
Author Kimon de Greef

Many thanks to Doubleday Books and NetGalley for sharing an advanced copy of Kimon de Greef’s wild and mind expanding book The Ego Trip: Psychedelic Toads, a Trail of Deaths, and the Guru Who Peddled Transcendence. Following in similar investigative books that explore the recent explosion in psychedelic therapy and tourism, de Greef takes readers down a less traveled path to enlightenment and psychedelic knowledge through the Sonoran Desert Toads, also known as Incilius Alvarius or previously known as Budo Alvarius, a species of toad that exudes a toxin that has psychedelic properties that are similar to those found in plants like ayahuasca. De Greef’s book not only takes readers on a trip to learn more about the history and misrepresentation of smoking toads (or sometimes licking them), but also about the self-appointed toad gurus who have swept in to the Sonoran Desert area and received the “blessings” of the Seri people, the supposed indigenous guardians of the toad medicine. Much like Ernesto LondoƱo’s Trippy: The Peril and Promise of Medicinal Psychedelics and John O’Connor’s A Short, Strange Trip, de Greef’s book not only examines the promises of enlightenment and new insights to be gained from these psychedelic substances found in nature, but also examines the psychedelic gurus and facilitators who lead these new therapeutic sessions, and the implications and consequences of taking plant medicine and traditions to those with psychological problems and mental illness. It leaves readers to question whether these individuals are really helping or exploiting others and their needs. De Greef’s reporting leaves us uncertain as to an exact answer, but it is clear that there are power and economic inequalities that still persist as a result of the recent book in psychedelic tourism and the emerging industry that supports it. Furthermore, I found de Greef’s questions and analyses important in examining the ways in which some of these facilitators take advantage of the increasing desire for personal insight, growth and knowledge, and how psychedelic substances have largely filled a void for these psychonauts.

At the center of this tale of toads is a charismatic but troubling physician named Octavio Rettig, whose own struggles with substance abuse were relieved through toad medicine. De Greef’s narrative is divided into two parts, with the first part exploring Octavio’s addiction battle and eventual rise to become a trusted purveyor of toad medicine to others who are sick and suffering with the approval of the Seri, a nomadic desert people who occupy land in and around the Sonoran Desert. I found this part of the book to be fascinating not only because of Octavio’s unique rise to psychedelic supremacy, but also because de Greef details the long, strange trip of 5-MeO DMT, the supposed God Molecule, that is found in not only toad venom, but also in plants and the molecule’s synthesis in labs. Unlike other long-lasting psychedelics, 5-MeO DMT is a much shorter trip with users experiencing an intense ego dissolution, often viewed as providing new insights and connections. In some of the latter half of the book, which details the attempts of pharmaceutical companies to patent and produce 5-MeO DMT for therapeutic purposes, researchers liken its powerful experiences and effects on the brain as a kind of system reset that possibly can be a powerful agent in helping individuals with significant depressive symptoms, especially those with treatment resistant depression. We not only learn more about the history of this intense psychedelic, but also about the Seri people, who were the supposed guardians of toad medicine and whose council granted Octavio special rights as a kind of shaman who can distribute toad medicine. De Greef’s research also takes us into the history of toad smoking and licking, which explores some of the misconceptions and fear mongering about the attempts to seek out this new, psychedelic experience, as well as some of the cultural and anthropological studies related to psychedelics and toad medicine. This was among some of the most interesting aspects of the book, and de Greef’s clear summary and analysis of the history and concepts helps readers understand the possibility and questions around the use of toad venom in ancient or pre-Columbian spiritual experiences from people like the Mayans and Olmecs. De Greef consults with well-known experts in the field like Andrew Weil and Wade Davis, as well as other well-known researchers whose work in Central and South America helped establish much of the scientific study of plant medicines of indigenous people. What is most fascinating, though, is through de Greef’s examination of the Seri people is that we find that there is not much evidence to support their use of toad venom in any kind of spiritual or religious experiences. The Seri people, who have inhabited the Sonoran Desert area for centuries, revered many other animals in their traditional ways, but there is no evidence that the toad was one of them. De Greef’s reporting indicates that Octavio likely brought toad medicine to the Seri people in order to help with the high rates of alcohol and drug addiction and used their traditional songs and imagery in his toad ceremonies, providing a kind of credibility to the idea that toad medicine is an ancient, indigenous practice. In fact, Octavio received letters from the tribal council indicating his skills as a practitioner of toad medicine, a credential he would use to travel the world and facilitate toad ceremonies for others who were interested in or in need of some kind of mystical experience to bring about change.

In the first half of the book, de Greef also details the complications that have arisen in trying to extract the toad venom, since it requires “milking” the toads by squeezing them. The toads are nocturnal and only come out during the rainy season, spending much of the year underground in the Sonoran Desert. Further complicating the issue is the fact that the Sonoran Desert has become an area used by cartels and coyotes to facilitate border crossings, and toad hunters have, at times, been abducted or experienced conflicts with both groups, making toad medicine a difficult and sometimes dangerous substance to obtain. As Octavio’s prominence rises in the world of toad medicine, de Greef describes how his ceremonies gradually take on a kind of rote-like practice, where he sometimes tries to take on as many customers as possible, many times ignoring or failing to watch over individuals in the throes of an intense, psychedelic experience. Furthermore, he incorporates other plant medicines in the process, which may have other effects on his participants. What was even more troubling was that as a physician, he seemed to do no intake or prior history to understand any possible physical or mental conditions that may impact the treatment. In fact, Octavio and some of the other practitioners seem to view toad medicine as a kind of panacea that can treat all conditions from addiction to diabetes and ADHD. As readers will learn, this cavalier approach to a powerful psychedelic has dangerous and tragic consequences.

The second half of the book was also interesting, but I enjoyed it less than the first half. While Octavio is still featured in the second half of the book, this section moves away from the Sonoran Desert and into the business world, where we learn more about the attempts of start-up pharmaceutical companies to bank on the growing trend of psychedelic therapies, and how new attempts to synthesize 5-MeO DMT has led to an increase in trials for this medicine. Among the strands in this story is the growing attempts to legitimize psychedelic medicine, and how the psychedelic toad community struggles with reigning in Octavio’s messianic behavior, which has resulted in injuries and deaths. It is interesting to learn more about how some of the pharmaceutical companies have attempted to take 5-MeO DMT to trials and to read about the outcomes of these experimental trials, but I found this aspect of the story a little more clinical and not as exciting as the first half of the story, where de Greef examines the history, rituals, and cult of toad medicine. In some ways, there are parallels between Octavio and these companies, who seemingly both seek to exploit the growing interest in psychedelic therapies and their role in self-exploration and actualization. As de Greef’s reporting and analysis demonstrate, there seems to be a fine line between the beneficial and the profitable approaches of both facilitator and companies. That is, while they both seem to want to improve outcomes and contribute to wellness of individuals, there’s also a need to make money, and when readers look beyond the visions and trails, we’re left wondering who benefits the most from toad medicine.

The Ego Trip is a fascinating book that incorporates scientific and true-crime reporting to explore the complications arising not only from a controversial and misunderstood approach to mental health and wellness, but also the rise of a complicated, guru-like man who has twisted traditional ways to create his own narrative and practices for toad medicine. De Greef’s reporting not only provides more insight into this misunderstood practice, but also provides readers with more clarity about the origins of toad medicine, and how practitioners like Octavio Rettig have twisted ambiguities and uncertainties about indigenous practices to carve out a new age practice that meets the needs of a growing crowd of psychonauts. De Greef presents compelling evidence to allow readers to draw conclusions about these practices as well as the kind of cult that Octavio has built over the past 15 years. It’s a fascinating look at this obscure, but growing community. Highly recommended! 





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